what is wrong ( ) you what is the matter( )you 用什么介词?

what is wrong ( ) you what is the matter( )you 用什么介词?
what is wrong ( ) you what is the matter( )you 用什么介词?

what is wrong ( ) you what is the matter( )you 用什么介词?
what is wrong (with ) you
what is the matter(with )you
两个空都填 with ,意思都是：你怎么了?

都填介词with
What is wrong with sb.?=What's the matter with sb.? 某人怎么了？